The underlying causes of Alzheimer's disease are not fully understood, but a good deal of evidence points to the accumulation of ?-amyloid, a protein that's toxic to nerve cells. ?-amyloid is formed by the activity of several enzymes, including one called BACE1. Most Alzheimer's disease patients have elevated levels of BACE1, which in turn leads to more brain-damaging ?-amyloid protein...
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